ImmunotherapyInstitute

— Protocol 8

Cryoablation for Cancer

Cryoablation: Revolutionizing Cancer Treatment with Cold Precision

A Minimally Invasive Treatment Using Extreme Cold to Kill Cancer

In the evolving landscape of cancer treatments, cryoablation stands as a beacon of innovation. This minimally invasive technique leverages extreme cold to annihilate cancer cells, effectively freezing and obliterating the diseased tissues. Known by various names including cryosurgery, percutaneous cryotherapy, or targeted cryoablation therapy, it offers a promising avenue in the fight against cancer.

Understanding Cryoablation: A Closer Look

Cryoablation, a versatile treatment, finds applications in addressing tumors located in diverse regions of the body, encompassing the kidneys, bones (including the spine), lungs, and breasts. It even proves effective in treating benign breast lumps known as fibroadenomas.

The underlying mechanism that potentially triggers an immune response through cryoablation is the distinctive manner in which it induces cell death. It orchestrates a dual approach, involving both necrosis and apoptosis. Necrosis facilitates the release of intracellular contents, sending out signals that potentially activate T cells, thereby fostering a targeted immune response against the cryoablated tissue.

The Cryoablation Procedure: A Glimpse into the Treatment

The cryoablation procedure is characterized by precision and minimal invasiveness. It involves the insertion of a slender, wand-like needle, known as a cryoprobe, directly into the cancerous tumor through the skin. This is followed by the infusion of a gas, either liquid nitrogen or high-pressure argon gas, into the cryoprobe, which freezes the diseased tissues.

To ensure accuracy in targeting the treatment sites within the body, physicians employ image-guidance techniques. These techniques, including ultrasound, computed tomography (CT), or magnetic resonance (MR), serve as navigational aids, guiding the cryoprobes to the precise locations, thereby enhancing the efficacy of the treatment.

Questions? We've got answers.

What is cryoablation?+

Cryoablation destroys tumors by freezing them. A thin needle-like probe is guided into the tumor with imaging, and extreme cold kills the cancer cells. Because it uses a small puncture instead of open surgery, recovery is usually faster.

Which cancers can cryoablation treat?+

Cryoablation is most often considered for small, well-defined tumors, such as some tumors of the kidney, liver, lung, prostate and bone. Our team reviews your imaging to decide if your tumor's size and location make you a candidate.

Is cryoablation painful?+

Cryoablation is minimally invasive and is done with anesthesia or sedation. Most patients have mild discomfort at the probe site afterward, which is usually managed with standard pain medicine.

How long is recovery after cryoablation?+

Many patients return to light activity within a few days. Recovery depends on the organ treated and your overall health, and our team gives you a specific plan.

Can cryoablation be combined with immunotherapy?+

Yes. Destroying a tumor can release cancer markers that the immune system may learn to recognize. That is why we often consider cryoablation as part of a broader plan that includes immune-based and supportive therapies.

How do you handle complications or side effects?+

Patients are monitored daily during treatment. Side effects are tracked, documented and addressed in real time, sometimes with medication adjustments, sometimes with supportive therapy, and occasionally by pausing a treatment. The treating physician reviews the patient's status every day the patient is on-site.

Can I continue treatments I'm already on at home?+

Usually yes, but it depends on the specific medication and how it interacts with our protocol. Bring a complete medication list to the consultation. We coordinate with your home physician where possible.

Will my treatment plan change while I'm here?+

Sometimes. Blood work, imaging and response markers are checked during your stay, and the protocol is adjusted if the data suggests it should be. Any meaningful change is reviewed with you before it's implemented.

How is my treatment plan decided?+

After we receive your medical records, imaging and pathology, your case is reviewed by the medical board. They draft a proposed protocol: which therapies, in what sequence, over how many days. You then have a consultation with the treating physician to review it, ask questions and adjust before anything begins.

Do you offer CAR-T therapy?+

Yes, we offer CAR-T therapy in addition to our broader autologous immunotherapy program. Both are built on the same core principle: collecting the patient's own immune cells, engineering or activating them to better recognize cancer, and reinfusing them to do the work. Which approach fits your case, and how it's delivered, is reviewed during the medical consultation.

What supportive therapies do you offer?+

IV vitamin C, ozone therapy, hyperbaric oxygen, peptide therapy, IV nutrition, metabolic support, lymphatic therapy and others, selected based on the patient's case, not applied as a fixed menu. These are supportive, not curative. They're used to help the body tolerate and respond to the core treatment.

Do you use radiation?+

Radiation is not delivered on-site. When radiation is part of the recommended plan, we coordinate with established radiation oncology centers and incorporate it into the broader protocol.

Do you use chemotherapy?+

We do, when it's the right tool for a given case, and we say so clearly. For some cancers, metronomic chemotherapy combined with immunotherapy is more effective than immunotherapy alone. We don't reject chemo as a category; we use it strategically.

Do you only treat late-stage or terminal patients?+

No. We see patients at every stage: newly diagnosed, in active treatment elsewhere, in remission and looking to lower recurrence risk, and patients who have exhausted conventional options. The protocol is adjusted to the situation.

How does diet affect my immune system?+

What you eat affects how well your immune system works. Highly processed foods, added sugars and certain fats can drive chronic inflammation, while a diet built on whole foods, vegetables and quality protein gives your body what it needs to repair tissue and fight disease. During cancer treatment, good nutrition also helps you maintain strength and tolerate therapy. That's why every patient's meals are planned by our clinical nutritionist.

Why are supplements part of the Institute nutritional plan?+

Supplements are an important part of your nutrition plan. We use a specialized line of supplements chosen for each patient. Our medical team considers your medical history, lab work, specific medical tests, genetics, physical condition, lifestyle, age, sex and type of disease.

Your supplements are reviewed and adjusted over time as your body responds and finds the balance it needs.

What are the characteristics of the Institute nutrition plan?+

Every plan is crafted for the individual patient. Our nutrition plan is:

  • Free of chemicals and preservatives
  • Made with organic fruits and vegetables
  • Made with hormone-free meat
  • Paired with personalized supplements
  • Made with metal and mercury free fish
  • Hypoallergenic
  • Gluten and dairy free to promote immune tolerance
  • Alkaline-focused, built around vegetables, fruits and whole foods
How do you create my nutrition plan?+

Your personalized nutrition plan is developed, reviewed and refined by our medical team together with our clinical nutritionist, kitchen staff and functionally trained chefs.

They take into account your needs during a stressful time, any nutritional deficiencies, the foods your body needs most, your allergies, and your personal preferences in taste and presentation.

What is the difference between metronomic chemotherapy and conventional chemotherapy?+

Conventional chemotherapy is given at the highest dose the body can tolerate, followed by a recovery break. Metronomic chemotherapy uses smaller doses given more frequently on a steady schedule.

Like any chemotherapy, metronomic chemo is systemic: it travels through the whole body. But this dosing approach causes fewer side effects than conventional schedules, and it's used to support the immune response rather than suppress it, which is why it pairs well with immunotherapy.

What kind of hyperthermia do you offer?+

We use Heckel whole-body hyperthermia, which raises your core body temperature using infrared heat. No sedation is needed, and you stay awake and alert throughout the session.

Hyperthermia is a well-established therapy, studied for decades and used in cancer centers around the world. Clinical trials have shown that combining hyperthermia with chemotherapy or radiation can improve results, and it also enhances the effect of immunotherapy.

Hyperthermia also supports the body's elimination process, which helps reduce the side effects of other treatments. Many patients say they feel better within the first few sessions.

Sessions typically last 2 to 4 hours. Hyperthermia is generally well tolerated. Side effects are usually mild and are reviewed with you before treatment.

What is the difference between the immunotherapy offered through your program and what my doctors are recommending at home?+

There are two main types of immunotherapy: pharmacological and autologous. We offer both, and we have seen great success with autologous immunotherapy.

In autologous cellular immunotherapy, we collect your immune cells, culture them, and infuse them back into your body. During that process, the cells are activated and trained to target and attack cancer cells.

Autologous cellular immunotherapy uses specific types of cells, mainly dendritic cells, NK cells and T lymphocytes. These cells act against cancer cells and recharge the immune system. When NK and T cells find a tumor cell, they attach to its membrane and release toxins that kill it, then move on to the next target.

Every case is different, which is why it's so important to review your specific situation. To find out if this therapy is right for you, call us or request a free case review.

What are the side effects of cancer treatment?+

Our program is designed to reduce side effects. Alongside your core treatment, we use supportive therapies that help your body tolerate treatment and recover, and you're monitored daily so any side effect is addressed right away.

Patients who have previously had chemotherapy receive a chemo-preconditioning program that helps reduce lingering effects such as nausea, fatigue, toxicity and anemia, so the body is in the best possible condition for treatment.

What kind of outcomes can patients expect?+

Every case is different, and no clinic can promise a cure. What we can say is that many of our patients achieve meaningful control of their disease, and some reach remission (no evidence of disease), while maintaining or improving quality of life. Outcomes depend on cancer type, stage and individual factors, and are never guaranteed. The best way to understand your specific situation is a case review with our physicians.

Can I undergo treatment at the Institute if I've had chemotherapy?+

Yes. Many of our patients are still on chemotherapy or have had it in the past, and many of our most successful cases had chemo before coming to us. Our treatments don't interfere with being on chemo the way many other treatments do. Our preconditioning program helps eliminate the toxic effects of previous chemotherapy and get the body into optimal condition for treatment.

Can the Institute treat stage IV cancer?+

Yes. Most of our patients come to us with stage IV disease. Each patient's outcome depends on their current health, medical history, eating habits and overall lifestyle, and our studies have shown that many of our cancer patients have reported benefit from our treatments.

For stage IV patients, time is of the essence. The sooner we review your case, the more options we're likely to have.

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